1 edition of Metabolism of amines in the brain found in the catalog.
Metabolism of amines in the brain
Published
1969
by Macmillan in London
.
Written in English
Edition Notes
Includes bibliographies.
| Statement | edited by G. Hooper. |
| Contributions | Hooper, Gerard, ed., British Pharmacological Society., Nordisk farmaceut-union. |
| Classifications | |
|---|---|
| LC Classifications | QP801.A48 M4 |
| The Physical Object | |
| Pagination | vii, 74 p. |
| Number of Pages | 74 |
| ID Numbers | |
| Open Library | OL5716636M |
| LC Control Number | 70360976 |
Abstract. 1. The effect of chlorpromazine (CPZ) on the metabolism of dopamine and 5-hydroxytryptamine in dog brain was investigated by following the concentrations of the acid metabolites of these amines, homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolylacetic acid, in the ventricular cerebrospinal fluid (C.S.F.) of dogs over a period of 5 hr after intravenous Cited by: A biogenic amine is a biogenic substance with one or more amine groups. They are basic nitrogenous compounds formed mainly by decarboxylation of amino acids or by amination and transamination of aldehydes and ic amines are organic bases with low molecular weight and are synthesized by microbial, vegetable and animal metabolisms. In food and beverages they are formed .
Abstract. The term catecholamine refers to a group of substances with low molecular weight that contain a catechol nucleus (i.e., two hydroxyl ions, on the 3- and 4-positions) and an amine on the side chain (Fig. 1). The numbering system begins with the carbon adjacent to the side chain (with the first carbon atom called alpha, the second beta, etc.) and rotates counterclockwise within the Author: J. C. de la Torre. Carnitine was detected at the beginning of this century, but it was nearly forgotten among biochemists until its importance in fatty acid metabolism was established 50 years later. In the last 30 years, interest in the metabolism and functions of carnitine has steadily by:
Amino acids are a part of the building blocks that make up proteins. Amino acids form polymers with peptide polymers are better known as proteins and represent, next to carbohydrates and fats, a vital nutrient and body amino acids, as suggested by their name, include a nitrogenous amino group in their base frame (NH2, NH, N), proteins are an important nitrogen donor. @article{osti_, title = {Metabolism of phencyclidine}, author = {Hoag, M K.P.}, abstractNote = {Phencyclidine (PCP) is a drug of abuse which may produce, in some users, a persistent schizophreniform psychosis. The possibility that long term effects of PCP are mediated by metabolic activation of the parent compound to reactive species is consistent with the demonstration of metabolism.
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations.
However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders Format: Hardcover. Purchase Metabolism of Amino Acids and Amines, Volume 17B - 1st Edition. Print Book & E-Book. ISBNBook Edition: 1.
This book discusses the physiology, biochemistry, and pharmacology of the biogenic amines. Organized into 39 chapters, this volume begins with an overview of the release of amines, which is implicated in functional disturbances characteristic of different Edition: 1.
Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations.
However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders.
The metabolism of brain tissue preparations in vitro; energy metabolism and coenzymes in relation to the nervous system; and lipid and fatty acid metabolism are also considered.
The book further tackles nucleic acid metabolism; protein and amino acid metabolism; and cholinergic and non-cholinergic Edition: 1. increased production in the brain. Protection of the brain from peripheral metabolism of catecholamine (hormone) is accomplished in this way, and the periphery is protected from catecholamines (transmitters) metabolism in the brain.
Serotonin (5-hydorxytryptamine) is a biogenic amine which differs from catecholamines by its indolic nucleus. Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines.
The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related Edition: 1. Xenobiotic Metabolism in Brain. Drug Metabolism Reviews27 (3), DOI: / Peter H. Yu, Alan A. Boulton.
Effect of trimipramine, an atypical tricyclic antidepressant, on the activities of various enzymes involved in the metabolism of biogenic by: Metabolism of Amines. I duction represented secondary amine. The primary amine was assumed to be the difference between the total amines and the sum of secondary and tertiary amines.
This method of estimating the primary amine was different from the procedure of Weber and. Amines participate in important metabolic and physiological functions in living organisms.
Polyamines are essential for cell proliferation, growth, renewal, and metabolism. They are involved in nearly every step of DNA, RNA, and protein synthesis, and regulate the. For several decades, however, neurochemists and pharmacologists have appreciated that in addition to the major amine neuromodulators a series of less well characterized amines derived from the metabolism of amino acids are also present in many tissues in the body, but especially in the brain Cited by: The clearest demonstration ofthis selectivity in the oxidative metabolism of aromatic amines and~ involves the metabolism of 2-acetylaminofluorene (AAF) byfour purified forms of rabbit cytochrome P (Johnson et al., Metabolism of Brain Peptides discusses neuropeptide metabolism in light of recent research.
It describes the processing mechanisms in the production of biologically active peptides. It details distribution of the variety of neuropeptides in the brain and comprehensively reviews the effects of these neuropeptides on behavioral and physiological Cited by: Metabolism of amines in the brain: proceedings of the symposium of the British and Scandinavian Pharmacological Societies, Edinburgh, July ; Author: Gerard Hooper ; British Pharmacological Society.
This article has been cited byother articles in PMC. Abstract. The metabolism of a number of biogenic amines has been simulated by using data obtained from studies of the individual enzymes from pig brain.
It is shown that β-hydroxylated amines such as noradrenaline and octopamine are metabolized primarily to the alcoholic metabolite whereas amines lacking this group [e.g. dopamine (3,4 Cited by: Final publisher's version, KB, PDF document.
Jacob Korf; There are indirect indications, that biogenic amines in the brain are concerned with pathological states such as depression (serotonin, 5HT and noradrenaline, NA) and Parkonsonism (dopamine, DA).
These indications were obtained from measurements of amines and Cited by: 6. Suggested Citation:"Vitamin B6 and Biogenic Amines in Brain Metabolism."National Research Council. Human Vitamin B6 Requirements: Proceedings of a gton, DC: The National Academies Press. doi: / The dihydropyridinepyridinium salt system [62,63] is an example of a site-specific prodrug, developed for brain penetration of amines (but that is also applicable to alcohols and carboxylic acids), which employs an oxidative pathway for prodrug localisation.
Application of this system to amines was illustrated for desipramine, amongst by: The principal amines which will be considered here in relation to neurological and psychiatric disease are the catecholamines, dopamine (DA) and noradrenaline (NA), and the indolealkylamine, Brain Amine Metabolism in Some Neurological and Psychiatric Disorders | SpringerLinkCited by: 8.
1 In vitro models (synaptosones, electrically stimulated brain slices and monoamine oxidase (MAO) preparations have been used to identify the sites of action of nomifensine on brain monoamine metabolism. 2 Nomifensine potentiates neurotransmission in noradrenergic and dopaminergic synapses by blocking catecholamine by:.
The effect of α‐melanocyte stimulating hormone (α‐MSH) on the metabolism of blogenlc amines in the rat brain B. E. Leonard Pharmacology Department, Organon International B. V., Oss, The NetherlandsCited by: Lipid Mediators and Their Metabolism in the Brain: Medicine & Health Science Books @ ed by: Glutamate is a neurotransmitter, so having an alternative way of removing amines (glucose-alanine cycle) is important, especially in the brain.
Leucine Like valine and isoleucine, leucine is an essential amino acid in humans.
